The thing I always liked was using the Amiga (and shift) buttons to control the pointer. Real handy when drawing and you need to get something in the right place. :-)
Before getting a hard drive I also used RAD a lot for Slam Tilt or anything that was on multiple disks.
For me the RAM disk is also invaluable (even better when using HappyENV!) :-D
The depth gadgets are something I could NEVER do without - either on the screen or on the windows. I was disappointed when I heard that the A1 won't have the screen depth gadget, so when I get one I guess I'll have to live without it. :-(