I actually hope that Amiga and Amigalike systems will become interesting for this kind of users again one day.
It will take a serious overhaul to get the AmigaOS API back among the state of the art architectures. MorphOS already implemented many must to have features and the whole OS was rewritten from scratch, but there is still a long way till it can compete with the giants out there with zillion dollars and users behind them.
It [AmigaOS API] has some advantages though, as it's slim, exceptionally responsive, and amazingly fast compared to others. Only future can tell which one will prevail :-)