Part of me agrees with many of the suggestions my fellow wedge Amiga owners have made: USB, SATA, GFX, CPU+, Audio, etc.
I have been working on making my A1200 a more usable system in the modern world, I have a Blizzard 040 accelerator, an IDEFix for improved IDE HD and multiple devices (slimline DVD/CDRW), a PCMCIA Wi-Fi card, and an Indivision 1200 AGA MK2cr so that I can use a somewhat modern 19" 4:3 LCD monitor. To round-out my A1200 a clock port USB controller, a 16bit sound card, and a graphics card would be favourable. But I have held off on purchasing some of these due to their high cost and limitations.
The problem with adding things to the A1200 is that there are inherent architecture limitations that are a bottleneck for a lot of the extenders; Maximum 2MB chip RAM limits screen resolution/colour depth, single Zorro slot, narrow IO bus means USB, network, IDE are slow, etc. Any and all extender solutions have to be clocked down so that they can operate within the A1200 in a workable manner. That's also where a lot of the cost originates from.
Rather than doing this thing piecemeal and with a crazy assortment of bolt-on extenders I would love something like the BoXeR board. The original BoXeR spec is a bit outdated by today's standards, but the concept is still valid; A melding of the Amiga AGA motherboard with the concepts of the Mediator/G-Rex PCI daughterboards, with some other architectural improvements (reduced bottlenecks). This type of hardware would get me very interested.
NATAMI was an awesome project but the (commercial) issue with NATAMI is that it doesn't provide an option to sell additional kit. A BoXeR-like board allows Amigakit to sell add-on cards.
To be perfectly honest, I am more interested in a BoXeR-like board, an ultimate AmigaOS 3.9 open platform board, than in an A1 X1000 or A1 X2000. It wouldn't be dirt cheap, but I sure as hell would rather have a nice clean slate than build my hobby PC on top of a 22 year old, can fail at any time, expansion limiting, proprietary hardware computer.
Lifting the 68k base to a higher standard will provide a better ecosystem to run the existing applications and could provide an incentive for a kickstarter to get OWB ported to OS 3.9, and would also be a nice board for AROS 68k.