IMO the only way for Amiga to once again become a mainstream OS is to port OS4.x to x86 and create classic card with a 68xxx based processor that could run all classic software.
Not worth it. You will need a complete rewrite to bring AOS up to modern standards. Add in the pricing of such a PCI-E card, your making the retail cost down right silly for 25 year old software. Only I can see that can remotely make some people happy is Anubis-OS and they need a heck of a lot more coders to get it up to speed.