It would have to be x86 for me. I don't understand all the fuss about ARM. If you going to change architecture at this point you might as well go for the most powerful.
With AmigaOS API, if you change the architecture from M68k (big endian) to PPC (also big endian), you can provide a CPU emulator to run system-friendly legacy applications - just like AmigaOS4 or MorphOS did.
If you change the architecture to x86 (little endian), you can't - you can only emulate the whole legacy machine (UAE), like AROS does.
The OS for ARM CPU can be either big or little edian, depending on the compiler toolchain; CPU supports both endianness. This is what makes ARM particularly interesting.