I went totally PC in 2000 when I heard Kid A by Radiohead and decided to start writing electronic music. I built a PC so I could run Reason. Now I'm totally Mac and use Reason and Record.
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moto
For me, music sequencing reached a pinnacle with OctaMED. Stuff that has come along since has undeniably become more feature rich, better sounding and been more professional (read boring), but I just can't use any of it.
There is something fundamental about columns of note events and hex command codes adjacent scrolling up the screen that I find intuitive in a way that no piano roll or notation format has ever achieved for me.
Thankfully, OctaMED does MIDI, else I'd probably never compose anything at all. I haven't really played with the concept, but I figured using a few standalone softsynths on my PC and controlling them via OMSS within UAE might be a laugh.