We can best assess the business viability of the thing if we can answer two questions:
1) What does the Amiga OS do better than any other.
2) What does the new board do better than any other.
Both of these questions had obvious answers for the original Amiga at the time of its launch.
Answer these two questions and the best markets to apply the new box to should become apparent.
Personally, I believe the described equipment is already obsolete. Unless the programmable silicon is uber-cool question 2 will have no answer and the thing will die.