danbeaver: I have an Amiga 1200 with a 60 MHz m68060, and I'd like my emulations to be at least as fast. AmigaNG don't run m68k NetBSD.
Oldsmobile_Mike: Yes, emulation is not great, and not being able to use JIT makes a huge difference.
ral-clan: WINE doesn't really emulate as much as it just calls native OS code via translation from Windows code. This translation adds minimal overhead, if it's like GNU/Linux ABI emulation on NetBSD / FreeBSD. This is how BSDs can be faster at running GNU/Linux programs than GNU/Linux sometimes.
https://wiki.winehq.org/FAQ#Is_Wine_slower_than_just_using_Windows.3FLikewise, there's very little CPU overhead for a guest OS in VirtualBox, so that shouldn't be an issue.
You're right about graphics - both emulated Amiga graphics and any graphics translations between VirtualBox or WINE and the host OS impact performance, but I have that set to minimum (skip frames, turn off collision detection, et cetera) because I don't use graphics for more than just a text screen and plan to run them headless.
I should clarify - what I wrote was wrong. My Windows 7 virtual machine is set up with the latest WinUAE, not FS-UAE, and FS-UAE under OS X is definitely faster than WinUAE on the same hardware. I'll play with settings more.