Personally I used 2 programs for a long time, both were the "Illustrator's" of their time..
One was by gold disk and it was called Draw! It was amazing because it has postscript output and it was a professional level tool at the time and did color postscript output.. ProVector and Draw plus were others..
Some of us used Cad programs for drawing for the longest time (Like X-CAD)..
I would also mention that fantavision was a vector program much like the original Amiga animation program that was called Aegis Animator.
Aegis Animator I consider the great grandfather to "Flash"... Fantavision was an improved Broderbund takeoff. Aegis Animator and a later program called Zoetrope was done by Jim Kent who is now famous for the Human Genome project. He also did a great amiga-like animation program called autodesk animator studio for the PC. He also did a vector animation program for the Atari ST (Cyber Paint and a version of Zoetrope I think), though I can't remember for sure.. Most all of these programs were 320x200x32/64 colors (fantavision did HAM). It proved you could do a lot animating lines curves and color cycling. I have to loook at Fantavision and see who did that for Broderbund.