I think the only non-autoconfig part of the Vampire is the RAM addition. And the reason it's done that way is because the chipset functionality is being slowly but methodically absorbed into the SAGA core. Would anyone care for 128 Megs of Chip RAM?
Seriously,
https://vimeo.com/206380147 shows the V500 working with a Picasso IV graphics card in an A2000.
https://vimeo.com/206998554 shows a Vampire system running Chocolate Heretic using a Prisma Megamix Z2 sound card. Memory cards work with it too, as do SCSI controllers and other old Z2 expansions.