In WinUAE you have to buffer all of the samples in Fast RAM to get the sound to work correctly. You may see similar problems in EUAE.
If you're talking about the AmigaOS 4 version of EUAE you can get better results by running
the Maestrix, setting the sound-playback to MaestroPro, set the sample buffer size to 4096 bytes and run it under the Petunia JIT compiler. (Note: when using a sound card emulation mode under OctaMED Soundstudio 1.03c, you cannot use synthsounds or hybrid-synth samples.)
