If you're planning on using AmigaOS 4, go with the Mediator. If you're planning on going with MorphOS on PowerUP, forget the Mediator and find some other expansion deck for it since MorphOS doesn't have drivers for the Mediator.
If you're going to have two systems, I'd forget the expansion deck and sound card for the A1200. It's more compatible with the old stuff using the AGA chipset and an '030 accelerator. 128 megs of RAM is possible on a Blizzard 1230, other accelerators may not be able to hold as much. Be sure to get the 3.1 ROMs though, since they contain many bug-fixes.
For your second system, try to find a PowerPC-based system either running MorphOS or AmigaOS 4. Since AmigaOS 4 is getting ready to ship (according to
this interview with one of the developers), I'd wait before committing to any PowerPC system as it may be accompanied by new hardware from another company besides Eyetech. (The AmigaOne series was discontinued for a reason, after all.)