Lasermice are massively better and easier to deal with. More accuracy = less stress on your tendons and nerves = less hand problems.
What I like about laser mice is their weight - they're extremely light in comparison to roller ball mice....so yes, easier to handle and less stress.
I have to disagree with the accuracy statement though. If you have clean mice balls with high Dots Per Inch then the balls win in my opinion. Just a shame they're heavier. Yes...you have to clean them once in a while, but it's a small price to pay.