Again, it all depends what you use it for. Really, the intent of the 14-bit mode was to overcome the fidelity issues imposed by the existing 8-bit mode. Viewed in that light, you really ought to calibrate your CyberSound driver and use that calibrated output to get the best fidelity from your system.
I have a Prelude1200, so I don't bother much with the 14 bit mode.

I have done calibrations in the past though, the most recent one was about 6 months ago where I calibrated my A600 (68000, 4MB ram, KS2) perfectly which took about 2 hours. I did it because I ordered an ACA620 (which is now back with Jens for a firmware fix) so would therefore be able to play stuff back easily through the 14 bit calibrated mode.
I never actually tried the ACA620 in that machine before having to return it for the fix, but as soon as I get it back I'll be trying it out. I got that A600 to play back uncalibrated 14 bit though (16 bit 28KHz stereo audio), albeit it had to take a breath every 4 seconds whilst it buffered up in 14 bit mode. :crazy:
Seriously though, the uncalibrated 14 bit output is fantastic when compared to standard 8 bit.