While MovieSetter is probably good, I find using programs with the onionskin feature better. Disney Animation studio has this, and so does (later) versions of DPaint.
DPaint is definitely the most full-featured 2D cel-animation program for the Amiga.
If you want to try vector 2d animation, get Fantavision.
Probably cant go wrong with deluxe paint for old school 2d animation. I was able to figure it out as a 14 year old so it can't be too difficult
