It's kinda cool that the SuperFX chip was designed by an Amiga guy (he made Starglider and Starglider 2 on the Amiga, kinda similar to Starfox don't you think?).
There are surely games out there that use OCS/ECS and require more than 1MB ChipRAM, some needing several megs of FastRAM too, although I can't list them off the top of my head. I like it when a game can take advantage of my expanded system though.
Dungeon Master 2 requires 2 megs of RAM I believe. It was labelled as an AGA game simply to avoid confusion, but it runs on ECS provided you have extra RAM.
As mentioned above, some games will have extra stuff like sound effects (Hired Guns and Walker spring to mind) too