MC6809 - First processor I coded assembly on. Easy enough for an 11 year old to program on!
MOS6502 - Disliked because of lack of 16 bit index registers and didn't like zero paged addressing. Apple2's weird video memory mapping didn't help me feel the love either.
i8088 - Yuck! Hated the instruction set and the stupid segment registers.
MC68000 - Absolutely loved this CPU. Is such a joy to program on. Great instruction set! K-SEKA and Dr. Pepper go hand in hand.
I Stopped programming assembly around 94, but other Memorable CPUs for one reason or another:
Original Pentium 90 -- quite a work horse and I paid way too much for this cpu!
* Celeron SLOT-1 CPUs - I remember burning on out with a peltier-cooler (condensation killed it). Was able to overclock like crazy!
AMD Athlon "Thunderbird" - got many years of great performance out of this chip.
* Pentium 4 - stupid lame chip that under performed at any Mhz and ran too hot.
Mac Mini's 1.4ghz PPC seems to be a real work horse running OS X as a media server for 3+ years!
Currently loving my 68060 CPU in my 1200 and 4000T