Indeed. Personally I ran my custom selfmade IDEFix HW without any interface buffers, and I had 3 HDDs and a CD-RW connected. It ran for years until I dismantled the A1200.
Sure, get buffered interface if you will, but remember that it (the interface buffering) has nothing to do with performance. Oh, and obviously things like Fast ATA will be faster, but that is not due to interface buffering.
