Since when has Blade Runner been obscure? 
Personally, I prefer the book that that movie was derived from.
If I want power, I'll stick with PPC or X86.
For 68K based Amiga software, the FPGA Replay Board looks ideal.
The Natami is likely to suffer the same problem that plagues most niche system, while it will run legacy software, the number of new packages developed specifically for it may be limited.