Dont forget in those megadrive/mega cd days it was not full of region checking bollox, i had more American and Jap games for my megadrive and mega cd than PAL games and they played fine on a normal tv.
Yeah, I've only come across a couple of US games that won't work on my European Mega Drive. They will simply display a message like "This game was does not work on a European console". I've never had any problems with the NTSC side of the problem though.