GG 486 runs just fine on my A1500 Apollo 2030@50MHz. It's basically a 25MHz SLC but I've clipped on a 50MHz SLC2 on top and it still works fine with all caches on.
I don't think you'll have any problem with an A4000T, I think it's a backplane problem with things like the RBM (doesn't work with the Eagle tower backplane either)... but you're wise to try and find out.