I've been running a SCSI-TV with an A570/Supra500RX/A500 since the early 90s. It still has the original 100MB HD with OS2.1. That drive has AmiFileSafe, a forerunner of PFS3.
The GVP may require a ROM update to access larger HDs.
I would always follow standard SCSI terminating practices regardless of 50 or 68 pin HDs.