I have been using PFS2 (yes, 2) for 10 years or more. It's much faster than FFS.
I had a problem only once with the partition where IBrowse caches files. To fix that partion, I had to reformat that whole drive (I could have left it alone with a dead partition. Nah, not me.) Since that time, I only cache browser files to the Ram disk. This works great and I've never had another hint of a problem.