Duke nukem poor performance

[zipper]

I use CGX4 but this is some kind of picasso wrapper?

Sort of false positive, it should support CGX as well as P96.
Do you have Cyberpatcher running?

[zipper]

Well, try it, because if I remember correctly the 68060 has even less instructions implemented than the 68040, which might very well explain the slowdown.

At least 060 Quake crawls without Cyber/oxypatcher.