It's still performance wasted on luxury.
I dare say you can't play games like Quake or Duke 3D from USB, since the USB protocols produce too much overhead.
You can repeat that as much as you like, but it doesn't turn make it any more real. Transferring via Mass Storage Device uses an "overhead" of a 31 byte command packet and a 13 byte status packet PER COMMAND. I.e. if you read 4 MB of data, you have to handle two extra packets out of 8192 bulk data packets. In my calculation that's a protocol overhead of 0,024%.
My Deneb did 8.5 MB/sec reading from MSD devices. That's almost as fast as the internal A4000T SCSI controller. You know what? Most of the time is spent on the data transfer and not on the protocol overhead. Raw bus speed.
Using a Deneb with an USB Ethernet dongle will get you the fastest Ethernet solution available for the Amiga (somebody posted a result of 1.8 MB/sec recently with Roadshow). You will get the cheapest sound card solution with USB Audio.
Oh whatever...