The A2091 SCSI controller needs the termination on it no matter how many hard drives you install. The place for the end termination is the last on the cable chain. Both ends of the SCSI cable need to be terminated and the A2091 is at one end of the cable.
http://www.sacc.org/2091-man.pdf has a user manual. I have not used one but what I have read they need a revision 6 rom ( prefer rev 7) to work with an OS2 or greater.