If there was an x86 based Amiga OS, I would port/develop applications for it. I am software developer by trade and it wasn't even until Apple went Intel that we started getting customers that owned Macs. They still need to run windows and a dual booting MacBook is a sweet thing.
Also, by going to x86 based Amiga, we could get a Java JVM for it and that would open the flood gates of applications and tools to use. Amiga OS working with a good implementation of Java would be a very desirable.
I agree I would at first limit to a subset motherboard and processor for initial driver support... but once its moved to x86, I think the sheer number of people wanting something new and original to work with could move the OS to a really influential install base.