I'm a big fan of OpalPaint, which requires an Opalvision card. Recently I managed to get TVpaint to work (it was my fault - asleep at the helm), and I have to say that it is fantastic.
I've been trying to decide what to do when I get my XE - I find Opalpaint so handy for somethings (rub throughs for instance) that I'll want to keep a "classic" amiga around.