Personally:
Using usb mass storage devices to boot off of - so so.
Ethernet - perfect 100%.
Sound - better buy a sound blaster external with its own power supply. No cheap usb dongles from ebay.
Accessing FAT thumbdrives - perfect.
Accessing large usb drives (ide/sata) - find a better filesystem than the fastfilesystem, it is too slow. PFS3 would do.
usb burners - yes, with frying pan. you must buy the full version. the demo is limited.
Scanners - did not try.
Wireless keyboard and mouse - much more comfortable than using the amiga combo.