I've never had any problems on A500s, A600s, A1200s, A3000/Ts, A4000/Ts with plain old <4GB hard drives, SCSI or IDE. Of course, I've never bothered with a Deneb either.
I did have a couple of issues with CF on an A1200, though for the most part it worked well enough also. I wouldn't bother with it in a case that has room for a real hard drive, though.
