The original Worms ran perfectly well on my A1200 for years, even from hard drive and with an 060 and Mediator installed - although it had to be run with no startup sequence or booted from the original floppies. Worms checks the amount of RAM available and loads more sounds into chip RAM accordingly if it finds more. It's entirely possible that your chip RAM expansion isn't behaving exactly as native RAM would, causing the machine to freeze. Is it possible to remove/disable the expansion?
I'll agree - Worms DC is the best version of Worms I've played on anything - and I've played quite a few!