Back on the subject of most annoying game, can we consider all the Amos PD games ever made as a contender?
DawnVideoPoker and Babenoid were great AMOS games (written by Richard Fhager). Wonderland was pretty good too.
I think Team 17's 'Worms' originally started off as an Amos game too. And now coming soon to the Nintendo DS and PSP (announced release date is 17th March).
To the most annoying games I would add any SEUCK game - all play identically but with slightly different sprites. All tedious and devoid of any gameplay.