There is no magic involved here, all you need is money, money you are prepared to lose as it will be a big gamble.
You might be able to license Natami's 060 circuitry to put on your accelerator card.
Instead of three accelerator cards for different amiga models you could have one card with three connectors to fit 1200/2000/3000/4000 to maximise your potential sales with one design.
Another possibility is a whole new replacement mainboard, leaking batteries and capacitors are accelerating the demise of old boards and a new board could incorporate superAGA graphics compatible with new SVGA monitors.
The continued high demand for amiga's on ebay suggests that the potential market is much larger than the membership here would have you believe.