In all the office-based jobs I've had, IE has been the only (officially supported) option for web browsing, and it's fine to use to get a bit of web browsing done in-between work tasks. Some heavier sites don't work so well with the version we use (IE 7 or 8, can't remember), but otherwise it's fine.
At home I mainly use Opera, with some usage of Firefox. My home web browsing experience is definitely enhanced by using these two browsers, tons of nice features that make browsing easier. One example off the top of my head is Speed Dial in Opera, if I want to open a new tab with YouTube I've got it set to Ctrl+7, Gmail is Ctrl+2, etc... Small things I miss at work include the shortcut Ctrl+Shift+T, which in Opera and Firefox re-opens the last tab you closed, useful if you closed it too quickly.
For all those concerned about Chrome being a tool to collect your web usage data, there's a really simple solution: Use SRWare Iron. It's basically Chrome without the privacy issues. Link here:
http://www.srware.net/en/software_srware_iron.php
