As everyone has stated, it depends on what you want to use it for, but personally, my best experience with an expanded amiga is/was my mediator equipped voodoofied a4k while it worked flawlessly, extremely responsive, even with the 030ec/25 mhz board in there, and with the 060, oh boy.
Personally i've decided that the best route for me and my 1200 that was supposed to stay stock, is to get the indivision aga, and add a 060 with loads of memory.