Depends. If they stupidly are hard coded to DF0: then it won't work ( the older the more probable). But for instance F1 GP could be put anywhere and assigned.
A few games like F-18, the "df0:" strings in the program could be edited to "f18:" or similar and then assigned. Some games will work to HD install them to the big RAD drive. Renaming the RAD volume name to "Work" will make some installs easier or keep them from failing. Some of the HD installs were poorly written.
You're blazing a seldom explored trail, don't give up! It is amazing to me that very few have embraced the RAD: as a way to dramatically improve performance.
It's not new just forgotten. Many smart Amiga users used a RAD back in the day especially programmers. I bet a 4 MB RAD would cut the compile time of SAS/C in 1/2 back then and the Amiga was probably one of the fastest C development systems on this side of 5 grand because of it.