There were some patches to fix some bugs and speed up Sim City 2000. Have a look on Aminet and the Amiga Future website. I'm unsure which of the patches is the newest at the moment, I looked into it a long time ago but forgot the details.
I even compared the speed of the game running in MacOS on the same Amiga and the Amiga version was quite snappy with the patches applied and FBlit running.