If it's an NTSC unit you are going to have issues with a lot of games that were made for PAL systems. Plenty of games will still work fine though, and you can easily compile your own Amiga game collection CDs to play on them, or download one of the available collections that users have made and released over the years which have hundreds of classic Amiga games accessible from a menu. Of course if the unit is NTSC then someone might have to make a collection that only includes compatible games.
Check out how easy it is though -
http://mygurumeditation.wordpress.com/cd32-toolkit-assistant-help/