I would never program for Reaction, what a laborious and unrewarding task that would be compared to writing something for MUI, which can be used on more Amiga OSs including Aros, MorphOS and AmigaOS 2. From the programming point of view as well as accessibility, MUI is by far the wiser choice, not to mention the configuration options to the user are second to none on any platform. MUI3.8 can still be registered online, and eventually Zune should replace MUI3.x on both OS3 and OS4 the way it does in Aros, and should have all the features of MUI4 in MorphOS.
The great thing about MUI/Zune is anyone can code for it and the interface should work on all Amiga systems, reaching the widest audience. You don't even need an Amiga to use it, just a PC running Aros will do. And Aros can run from a USB stick, so it's portable and you can test your system and programs on any PC without installing a thing on the hard drive.
Once Zune is enhanced to MUI4 standards you'll see much more useful and beautiful software ported to Aros, OS3 and OS4, like Ambient and Fab's OWB browser. We just need more poeple to donate towards the bounty:
http://www.power2people.org/projects/profile/54