If, as you suggest, the port would completely keep GTK+'s own object set without any wrapping around the native amiga GUIs, then the entire existing discussion about a MUI/Zune/Reaction GTK port and their cross-amiga portability is already totally irrelavent.
It
is quite irrelevant, indeed. The specificity of the AOS4 port has got nothing to do with MUI/Zune/Reaction, it's got to do with the new way libraries are handled in AOS4, and perhaps some 2d gfx API for compositing, plus some other AOS4 specific stuff that might come handy along the way.