Apart from Notator, Cubase and other Midi software, there isn't much to do with an ST(e) other than play games. MIDI is the one area where they shined and were better in than an Amiga. Back in the day, they also had some good--for the time--mono DTP programs. They have a totally different personality with a 640x400 mono monitor. Once I got an Amiga, I never used a color monitor with an ST again. Even a stock A500 beats anything but a Falcon in color graphics. On the other hand, I'd never use an Amiga for MIDI either. There's never been any other sequencer with timing like Notator.
I currently have a a Mega 4 ST and a Mega 4 STE both running Notator and a few midi utilities and nothing else. Both have internal hard drives--hard drives are to the Atari St what expanded memory and flicker fixers are to an Amiga: hard to find and expensive. They used a limited version of scsi called asci and asci to scsi boards are not easy to find, especially the good ones that can use modern scsi drives. Most don't support parity.
On the bright side, it is easy to make a cable that will connect an ST in mono to a vga monitor. Just the connectors and 3 resistors.