PageStream is the perfect (the only?) example of a commercial programme that supports multiple platforms without bias. It is an excellent effort that should be encouraged - so go buy it!
ATM I run PGS4 (68k) on an A1200 as well as via UAE on x86 and the A1. Really looking forward to runnning a PPC native version.
This is where all Amiga-ised factions need to get their act together. It should be a main aim to facilitate parallel development for AOS4/MorphOS/AROS/Amithlon without discriminating against any one particular version. We can't afford to force developers to chose - an ideal situation would be a KDE/Gnome type affair, where you can run software for "the other side" as long as you have a few libraries installed. Reliance on a common set of APIs would be beneficial to all (eg MUI/AHI etc).