Surely that depends on where they are. If they are in some inner loop, yes, if they are in some initialisation code or something called infrequently, does it matter so much?
Trapped instructions are slow all the time, everywhere and anywhere !
Watch by yourself !
Hopefully, OxyPatcher accelerate a lot, but still 5.6 time slower than a 32x32 routine untrapped...
Explanations :
Trapped mulu64 via the 68060.library: 1852
Real routine mulu64 untrapped : 6
Trapped mulu64 via the 68060.library and OxyPatcher running : 28
Real routine mulu64 untrapped with OxyPatcher running : 5
Ouch !