that would be a really nice idea!
to have very slim pci expansion with side mounted minipcibut only one would fit for video sound or ethernet
you would have to cut a hole in back desktop case. Im qiute sure that a small pci card would fit inside like without the backplane etc.
Some PCI card will work with cabled connection as some graphics cards have cabling on the actual output anyway like bit cable for the vga d-sub etc.
Regards