Disclaimer: This all happened a long time ago.
I remember reading about someone building a sampler connected to the joystick port. So, in my ignorance and lack of technical knowledge, I hardwired a microphone to the joystick port (tried various pins), started Audio Master and *puff* out came the blue smoke of death.
I also gave the same computer some serious beating after coding for hours (without saving) followed by the beloved guru meditation. Oh, the anger...
And for a while the Agnus overheated all the time. Solved it with a home made fan (disk drive motor and some cardboard) to keep it cool. The motor was just balanced on top of the Agnus with the wires hanging loose inside the miggy. Amazingly no shorts, and it was just enough cooling to keep it stable.
She survived everything and is still in my posession. :-)