FWIW, Vesalia sells the ACard 7730A.
http://www.vesalia.de/e_acardsata.htmThe ACard stuff is top-notch, and I would assume they've tested it. I have a 7730AS running a DVD drive attached to my MKIII. Note, the AS and A are different: the AS will run optical drives, only.
EDIT: Correction, the AS is a different series, but the same holds true. I have a 7732 which is ODD, only. In any case, I have not used a hard drive with the ACard on an Amiga.