In my experience with Classics, Deneb, and DMA vs. PIO, you really don't gain much by using the Deneb in DMA mode. When you are driving these devices so fast on the Classic systems your CPU is still being used quite a bit and DMA vs. PIO is about a 5% difference in CPU usage.
It's a general lack of CPU horse power and other sub-system slowness (like Zorro III) that are more of an issue. My recent networking tests using a Deneb in DMA mode (OS 3.9) and PIO mode in AmigaOS 4.1 Classic showed only about a 5% drop in CPU usage in DMA mode.
I cannot provide quantitative results at this moment, but qualitatively I experience a huge difference between PIO and DMA mode on system performance when transferring files to and from USB drives. (Also, USB sound is much better for me under DMA.)