There's tons of info Re: installation of this here on A.org. The search engine here is your friend :-)
But no, no need to fully remove your mobo. Being the careful and semi-anal chap I am, I did cut away some of the RF shield and stuck a rubber tab or two on the Indivision itself as to avoid any potential shortings.
Other main issue is if you have a CBM or HP made Lisa. You may have to shave away some of the socket to get it to fit snugly, but I believe with this latest batch of FF/SD's, that issue may have been corrected. Good luck!