No, usb scanners doesn't work with AmigaOS4.x, on morphos/aros/amigaos3.x there is usbwrap.class which creates usbraw.device and driver can communicate with scanner via this device. AmigaOS4.x doesn't have such a class/device so i can only work scsi scanner now. Thylacine which uses 68k version of Sirion has similar device: usbscanner.device but afaik it doesn't work with AmigaOS4.x.
There is native AmigaOS4.x SCANdal version available on OS4Depot, should work with scsi scanners.