My vote is for a NATAMI based new Amiga running AOS3 or AROS-68k. It should be able to use all the latest technologies, USB, SATA, DDR3 RAM, GIG Ethernet, 802.3N Wireless. Whatever OS is chosen should have a future map including 64-bit, multi-core, Tablet capability etc... I know this is a tall order, but one can only dream.